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KMID : 1142020220570030229
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Blood Research
2022 Volume.57 No. 3 p.229 ~ p.234
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Association of CD40 gene polymorphisms and immune thrombocytopenic purpura in the adult Egyptian population
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Ellithy Hend Nabil
Yousry Sherif Mohamed
Abdel-Aal Asmaa
Tawadros Lelian
Momen Nouran
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Abstract
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Background: The pathophysiology underlying primary adult immune thrombocytopenic purpura (ITP) has not yet been identified. However, many mechanisms affect the immune system, causing defective tolerance to self-platelets and megakaryocytes. Cluster of differentiation 40 (CD40) contributes to both humoral and cell-mediated immune responses.
Methods: This case?control study was conducted to detect rs4810485G>T and rs1883832C>T polymorphisms of CD40 in Egyptian patients with persistent/chronic ITP to clarify their possible association with chronic disease evolution. This study included 50 patients with persistent/chronic ITP and 50 healthy controls. Genotyping was performed using the polymerase chain reaction?restriction fragment length polymorphism technique.
Results: Genotyping of rs1883832 and rs4810485 revealed no statistically significant differences between the two groups. However, combined gene polymorphism genotyping showed a statistically significant difference between the two groups (P<0.01).
Conclusion: Our results indicate a strong association between the combined polymorphism of both genes and susceptibility to developing ITP among adult Egyptian patients. Targeting this pathway using novel therapeutic approaches is promising.
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KEYWORD
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CD40, rs1883832, rs4810485, Polymorphism, Chronic ITP
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